I use a Fujitsu N series notebook with a 3.0Ghz processor and 768MB RAM.  I like the fujitsu's because they didn't worry about making it light or battery efficient at the expense of processor speed or compatibility.  It's big and bulky, but just what I wanted.  I had many problems trying to use a Dell laptop.  Something about the power supply interferes with my amps.  I know it's the power supply becase I converted one for my Fujitsu and had the same strange noise (High pitched shreiking).  I have had lot's of problems with the little 4 pin Firewire ports all PC laptops have...they keep breaking after repeated use, so now I have to use a pcmcia firewire card.

I have an M-Audio Firewire 410 audio interface.  I like it a lot...very dependable and the preamps are good.  I hear almost no difference in sound when running a guitar straight through it into an amp.  I can also get the latency very low...A 64 sample buffer gives about 4ms of latency - which I am not a good enough guitarist to notice.  Latency isn't as noticable playing keyboards because the sound doesn't need to go into the computer first, cutting it down to 2ms.  Also, my fingers interpret latency as the weighted action of the piano even when it's as high as 12ms (Which most player would notice).  Sometimes when I have trouble or I'm lazy I will use the built-in audio of the Fujitsu along with the ASIO 4 All driver.  It increases my latency to 8ms (4 for keys) but needs less setup.

I use Plogue Bidule to host my plugins.  It's the next best thing to a bunch of stompboxes and patch cables.  I have my rig layout saved so I can quickly bring it up before a show.  When I'm experimenting with new setups it's easy to draw in a patch cable from one effect to the next.  Plus I can assign any knob on my MIDI controllers to adjust any plugin parameter.

I'm in a few different bands playing keyboard, guitar, or both.  For my guitar rig I run my cheapo 1990 Jap Strat straight into the FW410 preamp.  I then run the FW410 headphone output (Through a regular instrument cable) to a tube amp (A 61 Fender Super silverface or a 63 Ampeg Jet).  I have not yet found any amp simulators I have found worthy of a show...I've tried Amplitube, Guitar Rig, SimulAnalog, Green Machine, Warp, and Voxengo.  They do however work well to spice up the sound or add overdrive.  I use Amplitube because it can hang with the others sonically and uses much less processor - especially the reverb.  Guitar Rig seems like the best for features and sound though.  I'd love to not have to bring a tube amp, but there simply is no substitute - and that's coming from an uber-nerd. 

For effects control while playing guitar I use a modified Evolution/M-Audio UC-33 controller.  All the knobs and sliders are programmable so I have more control over the effects than I ever use onstage.  I also have a Yamaha MFC-10 MIDI foot controller that I use for the buttons - they control my Loopy Llama plugin's record, reset, and tap tempo buttons.  It also has inputs for up to 4 pedals, which can control anything.  Sometimes I'll just work the UC-33 sliders with my toes rather than plug in the pedals.

 I use the Yamaha volume pedals for any of my setups.  I set one pedal for volume and sometimes have another to control the amount of reverb, delay, or tremolo.  If I'm playing keyboards I'll use 2 pedals to control piano and organ volume seperately.  If I'm looping with the Loopy Llama I'll have a pedal to control the volume of the loop...or several pedals for several instances of the Loopy Llama.

If I'm playing keyboards I use a modified M-Audio Keystation 88 for pianos and an Evolution/M-Audio MK-461C for organ/synth.  These 2 have enough built in knobs so that I don't need the above controllers, but I did add Yamaha volume pedal inputs to 2 knobs on the Keystation 88.

As my keyboard instruments I use Native Instruments B4 for organ and Kontakt for rhodes piano, vibes, horns, and any other samples.  For Piano I use Steinberg's The Grand, which I like much better than any sample set I've tried with Kontakt - including the Bosendorfer, Fazioli, Nemesys GigaPiano and others.  My rhodes piano sample is home-made from my beloved suitcase 71 rhodes with the pickups super close to the tines so it's ronchy.  I also recommend the purgatory creek rhodes piano.  Most other rhodes samples seem to go for that clean, sugary, Steely Dan kind of sound that makes me want to retch.

My guitar and all of the above instruments are then routed through an effects section in this order:  The TremoLlama for tremolo.  Amplitube to dirty up the rhodes or guitar and add distortion or wah.  The Delay Llama for delay.   Another instance of Amplitube just for reverb (it's very low processor and a useful verb for the stage).  Then one or more Loopy Llama's for looping or reverse effects.